Background

Chronic Kidney Disease (CKD) is a major risk factor for cardiovascular morbidity and mortality. Patients with CKD undergoing Percutaneous Coronary Intervention (PCI) often experience higher procedural complications and adverse clinical outcomes compared to individuals with normal renal function.

Objective

To evaluate short-term and intermediate-term outcomes of PCI among patients with varying stages of CKD.

Methods

A prospective observational study was conducted involving 320 consecutive CKD patients who underwent PCI between January 2023 and December 2024. Patients were categorized according to estimated glomerular filtration rate (eGFR). Primary endpoints included Major Adverse Cardiovascular Events (MACE), contrast-induced nephropathy (CIN), target lesion revascularization (TLR), and all-cause mortality at 12 months.

Results

Mean age was 64.2±10.8 years. Diabetes mellitus was present in 71.9% of patients and hypertension in 86.3%. Procedural success was achieved in 95.9% of cases. Contrast-induced nephropathy occurred in 11.6% of patients. One-year MACE rates increased significantly with worsening CKD stage (p<0.001). Mortality was 4.2% in CKD stage 3, 9.8% in stage 4, and 17.5% in stage 5.

Conclusion

PCI remains feasible and effective in CKD patients; however, advanced CKD is associated with increased mortality, MACE, and renal complications. Careful patient selection and renal-protective strategies are essential.