Background

Peripheral Artery Disease (PAD) affects over 230 million individuals worldwide and is associated with significant morbidity, mortality, limb loss, and reduced quality of life. Endovascular therapy has emerged as the preferred first-line revascularization strategy for many patients due to its minimally invasive nature and favorable clinical outcomes.

Objective

To evaluate contemporary endovascular treatment strategies for PAD and assess procedural success, limb salvage, patency rates, and long-term clinical outcomes.

Methods

A prospective multicenter study enrolled 500 patients with symptomatic PAD undergoing endovascular intervention between January 2020 and December 2024. Clinical, angiographic, procedural, and follow-up data were analyzed. Primary endpoints included primary patency, limb salvage, target lesion revascularization (TLR), and major adverse limb events (MALE).

Results

Technical success was achieved in 96.8% of procedures. One-year primary patency was 84.2%, while limb salvage reached 94.5%. Major adverse limb events occurred in 8.6% of patients. Drug-coated balloons and drug-eluting stents demonstrated superior patency compared with conventional balloon angioplasty.

Conclusion

Contemporary endovascular management provides excellent procedural success and favorable long-term outcomes in patients with PAD. Advances in imaging, atherectomy, drug-coated technologies, and intravascular devices continue to improve patient outcomes.